Construction and application of adenoviral and lentiviral vectors to deliver transforming growth factor β3 and type I collagen-targeting SHRNA for engineered articular chondrogenesis
In this dissertation, we aim to induce type I collagen (Col I)-suppressed chondrogenesis in synovium-derived mesenchymal stem cells (SMSCs) or chondrocytes within 3-dimensional (3D) alginate hydrogel system with the use of adenoviral and/or lentiviral vectors to deliver both transforming growth fact...
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| Format: | Theses and Dissertations |
| Language: | English |
| Published: |
2011
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| Online Access: | https://hdl.handle.net/10356/44620 |
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| Institution: | Nanyang Technological University |
| Language: | English |