Access to pyridines via DMAP-catalyzed activation of α-chloro acetic ester to react with unsaturated imines

Access to pyridines via DMAP-catalyzed activation of α-chloro acetic ester to react with unsaturated imines

Facile access to trisubstituted pyridines from α-chloro acetic ester and unsaturated imines is achieved. DMAP-catalyzed activation of ester to form an enolate intermediate constitutes a key reaction step. On the application side, the wide availability and low cost of the substrates and catalysts mak...

Full description

Saved in:
Bibliographic Details
Main Authors: Chi, Robin Yonggui, Hao, Lin, Chen, Xingkuan, Chen, Shaojin, Jiang, Ke, Torres, Jaume
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2014
Subjects:
DRNTU::Science::Biological sciences
Online Access:https://hdl.handle.net/10356/79664
http://hdl.handle.net/10220/23927
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English
Description
Summary:Facile access to trisubstituted pyridines from α-chloro acetic ester and unsaturated imines is achieved. DMAP-catalyzed activation of ester to form an enolate intermediate constitutes a key reaction step. On the application side, the wide availability and low cost of the substrates and catalysts make this method very attractive.

Similar Items