Access to pyridines via DMAP-catalyzed activation of α-chloro acetic ester to react with unsaturated imines

• Main Authors: Chi, Robin Yonggui, Hao, Lin, Chen, Xingkuan, Chen, Shaojin, Jiang, Ke, Torres, Jaume
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/79664; http://hdl.handle.net/10220/23927
• Institution: Nanyang Technological University

Facile access to trisubstituted pyridines from α-chloro acetic ester and unsaturated imines is achieved. DMAP-catalyzed activation of ester to form an enolate intermediate constitutes a key reaction step. On the application side, the wide availability and low cost of the substrates and catalysts mak...