Molecular mimicry-based repositioning of Nutlin-3 to anti-apoptotic Bcl-2 family proteins
The identification of off-target binding of drugs is a key to repositioning drugs to new therapeutic categories. Here we show the universal interactions of the p53 transactivation domain (p53TAD) with various antiapoptotic Bcl-2 family proteins via a mouse double minute 2...
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| Main Authors: | , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2012
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/79957 http://hdl.handle.net/10220/8736 |
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| Institution: | Nanyang Technological University |
| Language: | English |