Oncofetal HMGA2 as a key regulator of telomere stability through control of DNA topology
Faithful replication of the whole genome is fundamental to maintain the genome integrity. During this process, the replication forks may encounter various endogenous and exogenous factors that could lead to replication fork stalling. Telomeres in particular experience numerous replication and topolo...
Saved in:
Main Author: | Dharshana, Ramani Priya |
---|---|
Other Authors: | Peter Droge |
Format: | Theses and Dissertations |
Language: | English |
Published: |
2018
|
Subjects: | |
Online Access: | https://hdl.handle.net/10356/89230 http://hdl.handle.net/10220/46217 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Nanyang Technological University |
Language: | English |
Similar Items
-
Oncofetal HMGA2 attenuates genotoxic damage induced by topoisomerase II target compounds through the regulation of local DNA topology
by: Ahmed, Syed Moiz, et al.
Published: (2021) -
Novel functions of the oncofetal HMGA2 protein in genome stability
by: Yu, Haojie
Published: (2014) -
Oncofetal HMGA2 effectively curbs unconstrained (+) and (−) DNA supercoiling
by: Zhao, Xiaodan, et al.
Published: (2018) -
Oncofetal HMGA2 effectively curbs unconstrained (+) and (-) DNA supercoiling
by: Zhao X., et al.
Published: (2020) -
The FGFR inhibitor PD173074 binds to the C-terminus of oncofetal HMGA2 and modulates its DNA-binding and transcriptional activation functions
by: Ahmed, Syed Moiz, et al.
Published: (2023)