N-heterocyclic carbene catalyzed C-glycosylation : a concise approach from Stetter reaction

• Main Authors: Vedachalam, Seenuvasan, Tan, Shi Min, Teo, Hui Ping, Cai, Shuting, Liu, Xue-Wei
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2013
• Online Access: https://hdl.handle.net/10356/97333; http://hdl.handle.net/10220/10599
• Institution: Nanyang Technological University

Described herein is the first example of an organocatalytic approach for acylanion addition to the anomeric carbon of 2-nitroglucal using an N-heterocyclic carbene catalyst. Control over the reaction conditions gives β-selective and nitro-eliminated C-glycosides, providing opportunities to produce n...