Importance of H-abstraction in the final step of nitrosoalkane formation in the mechanism-based inactivation of cytochrome P450 by amine-containing drugs

The metabolism of amine-containing drugs by cytochrome P450 enzymes (P450s) is prone to form a nitrosoalkane metabolic intermediate (MI), which subsequently coordinates to the heme iron of a P450, to produce a metabolic-intermediate complex (MIC). This type of P450 inhibition, referred to as mechani...

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Bibliographic Details
Main Authors: Xu, Kai, Hirao, Hajime, Thellamurege, Nandun, Chuanprasit, Pratanphorn
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2014
Subjects:
Online Access:https://hdl.handle.net/10356/97420
http://hdl.handle.net/10220/18414
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Institution: Nanyang Technological University
Language: English

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