Predicting Drug Combination Index and Simulating the Network-Regulation Dynamics by Mathematical Modeling of Drug-Targeted EGFR-ERK Signaling Pathway

• Main Authors: Huang, L, Jiang, Y, Chen, Y
• Other Authors: PHARMACY
• Format: Article
• Published: 2020
• Subjects: antineoplastic agent; B Raf kinase; epidermal growth factor receptor; mitogen activated protein kinase; protein kinase inhibitor; cell proliferation; computer simulation; drug effect; human; metabolism; signal transduction; theoretical model; tumor cell line; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Proliferation; Computer Simulation; Extracellular Signal-Regulated MAP Kinases; Humans; Models, Theoretical; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Receptor, Epidermal Growth Factor; Signal Transduction
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/173946
• Institution: National University of Singapore

10.1038/srep40752