Silica Gel-Mediated Hydroamination/Semipinacol Rearrangement of 2-Alkylaminophenylprop-1-yn-3-ols: Synthesis of 2-Oxindoles from Alkynes and 1-(2-Aminophenyl) Ketones
2-Alkylaminophenylprop-1-yn-3-ols, prepared from the lithium diisopropylamide (LDA)-mediated 1,2-addition of alkynes to 1-(2-aminophenyl) ketones, can be converted to 3,3-disubstituted 2-oxindoles by using silica gel in n-hexane/ethyl acetate (20:1 v/v) as the reaction medium. The utility of the app...
Saved in:
Main Authors: | Susanti, Dewi, Ng, Linda Li Ru, Chan, Philip Wai Hong |
---|---|
Other Authors: | School of Physical and Mathematical Sciences |
Format: | Article |
Language: | English |
Published: |
2014
|
Subjects: | |
Online Access: | https://hdl.handle.net/10356/101213 http://hdl.handle.net/10220/19716 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Nanyang Technological University |
Language: | English |
Similar Items
-
Silica gel-mediated hydroamination/semipinacol rearrangement of 2-alkylaminophenylprop-1-yn-3-ols : synthesis of 2-oxindoles from alkynes and 1-(2-aminophenyl) ketones
by: Susanti, Dewi, et al.
Published: (2014) -
1-(2′-Anilinyl)prop-2-yn-1-ol rearrangement for oxindole synthesis
by: Kothandaraman, Prasath, et al.
Published: (2013) -
Silver acetate catalyzed hydroamination of 1-(2-(Sulfonylamino)phenyl)prop-2-yn-1-ols to (Z)-2-methylene-1-sulfonylindolin-3-ols
by: Susanti, Dewi, et al.
Published: (2013) -
[Cp*RhCl2]2-catalyzed alkyne hydroamination to 1,2-dihydroquinolines
by: Kumaran, Elumalai, et al.
Published: (2015) -
Activation of alkynes with [Cp*MCl2]2 (M=Rh or Ir) towards hydroamination reactions
by: Kumaran Elumalai
Published: (2014)