An antimicrobial helix A-derived peptide of heparin cofactor II blocks endotoxin responses in vivo
Host defense peptides are key components of the innate immune system, providing multi-facetted responses to invading pathogens. Here, we describe that the peptide GKS26 (GKSRIQRLNILNAKFAFNLYRVLKDQ), corresponding to the A domain of heparin cofactor II (HCII), ameliorates experimental septic shock. T...
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Main Authors: | Papareddy, Praveen, Kalle, Martina, Morgelin, Matthias, Schmidtchen, Artur, Malmsten, Martin, Singh, Shalini |
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其他作者: | Lee Kong Chian School of Medicine (LKCMedicine) |
格式: | Article |
語言: | English |
出版: |
2014
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在線閱讀: | https://hdl.handle.net/10356/103671 http://hdl.handle.net/10220/19290 |
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