β-Carbon activation of saturated carboxylic esters through N-heterocyclic carbene organocatalysis

The activation of the α-carbons of carboxylic esters and related carbonyl compounds to generate enolate equivalents as nucleophiles is one of the most powerful strategies in organic synthesis. We reasoned that the horizons of chemical synthesis could be greatly expanded if the typically inert β-carb...

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Bibliographic Details
Main Authors: Xu, Jianfeng, Zhu, Tingshun, Leong, Wendy Wen Yi, Chi, Robin Yonggui, Fu, Zhenqian
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2013
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Online Access:https://hdl.handle.net/10356/105761
http://hdl.handle.net/10220/17073
http://dx.doi.org/10.1038/nchem.1710
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Institution: Nanyang Technological University
Language: English

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