Pulsed SILAM reveals in vivo dynamics of murine brain protein translation

• Main Authors: Ng, Ser Sue, Park, Jung Eun, Meng, Wei, Chen, Christopher P., Kalaria, Raj N., McCarthy, Neil E., Sze, Siu Kwan
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; Protein Identification; Peptides and Proteins
• Online Access: https://hdl.handle.net/10356/142786
• Institution: Nanyang Technological University

Identification of proteins that are synthesized de novo in response to specific microenvironmental cues is critical for understanding molecular mechanisms that underpin vital physiological processes and pathologies. Here, we report that a brief period of SILAM (Stable Isotope Labeling of Mammals) di...