A 3D fiber-hydrogel based non-viral gene delivery platform reveals that microRNAs promote axon regeneration and enhance functional recovery following spinal cord injury

• Main Authors: Zhang, Na, Lin, Junquan, Lin, Vincent Po Hen, Milbreta, Ulla, Chin, Jiah Shin, Chew, Elaine Guo Yan, Lian, Michelle Mulan, Foo, Jia Nee, Zhang, Kunyu, Wu, Wutian, Chew, Sing Yian
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Biological sciences::Cytology; Engineering::Chemical engineering::Biochemical engineering; Science::Biological sciences::Molecular biology; Hydrogel; RNA Interference; Neural Tissue Engineering; Electrospinning; RNA Sequencing
• Online Access: https://hdl.handle.net/10356/150957
• Institution: Nanyang Technological University

Current treatment approaches toward spinal cord injuries (SCI) have mainly focused on overcoming the inhibitory microenvironment that surrounds lesion sites. Unfortunately, the mere modulation of the cell/tissue microenvironment is often insufficient to achieve desired functional recovery. Therefore...