Substrate-binding glycine residues are major determinants for hydrolase and ligase activity of plant legumains
Peptide asparaginyl ligases (PALs) are Asn/Asp(Asx)-specific ligases that are useful for precision modifications of proteins and live-cell surfaces. PALs share high sequence and structural similarity to legumains, asparaginyl endopeptidases (AEPs) that primarily hydrolyze peptide bonds after Asx, th...
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Main Authors: | Hemu, Xinya, Chan, Ning-Yu, Liew, Heng Tai, Hu, Side, Zhang, Xiaohong, Serra, Aida, Lescar, Julien, Liu, Chuan-Fa, Tam, James P. |
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Other Authors: | School of Biological Sciences |
Format: | Article |
Language: | English |
Published: |
2023
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/164031 |
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Institution: | Nanyang Technological University |
Language: | English |
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