Nanoparticle Vaccines Encompassing the Respiratory Syncytial Virus (RSV) G Protein CX3C Chemokine Motif Induce Robust Immunity Protecting from Challenge and Disease

• Main Authors: Jorquera P.A., Choi Y., Oakley K.E., Powell T.J., Boyd J.G., Palath N., Haynes L.M., Anderson L.J., Tripp R.A.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Published: 2019
• Subjects: CX3C chemokine; gamma interferon; interleukin 4; Respiratory syncytial pneumovirus G protein nanoparticle vaccine; respiratory syncytial virus vaccine; unclassified drug; animal cell; animal experiment; animal model; animal tissue; antibody response; article; CD4+ T lymphocyte; CD8+ T lymphocyte; controlled study; cross protection; drug efficacy; drug safety; enzyme linked immunospot assay; eosinophilia; female; infection prevention; lung; mouse; nonhuman; protein blood level; protein motif; Respiratory syncytial pneumovirus; respiratory syncytial virus infection; Th1 cell; Th2 cell; vaccination; virus neutralization; virus replication; Animals; Antibodies, Neutralizing; Bronchoalveolar Lavage; CD8-Positive T-Lymphocytes; Chemokines, CX3C; Epitopes; Female; Interferon-gamma; Interleukin-4; Lung; Mice; Mice, Inbred BALB C; Nanoparticles; Respiratory Syncytial Virus Infections; Respiratory Syncytial Virus Vaccines; Respiratory Syncytial Viruses; Th1 Cells; Th2 Cells; Viral Fusion Proteins
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161268
• Institution: National University of Singapore

10.1371/journal.pone.0074905