The CTLA-4 and PD-1/PD-l1 inhibitory pathways independently regulate host resistance to Plasmodium-induced acute immune pathology

• Main Authors: Hafalla J.C.R., Claser C., Couper K.N., Grau G.E., Renia L., de Souza J.B., Riley E.M.
• Other Authors: MICROBIOLOGY AND IMMUNOLOGY
• Format: Article
• Published: Public Library of Science 2020
• Subjects: cytotoxic T lymphocyte antigen 4; gamma interferon; programmed death 1 ligand 1; Cd274 protein, mouse; differentiation antigen; PD 1 antigen, mouse; PD-1 antigen, mouse; animal cell; animal experiment; animal model; animal tissue; article; Bagg albino mouse; brain malaria; C57BL 6 mouse; CD8+ T lymphocyte; controlled study; homeostasis; host resistance; immune response; lymphocyte depletion; mouse; nonhuman; Plasmodium berghei infection; protein expression; T lymphocyte activation; animal; C57BL mouse; erythrocyte; immunology; lymphocyte activation; malaria; metabolism; microbiology; parasitology; pathogenicity; pathology; Plasmodium berghei; Mus; Animals; Antigens, CD274; Antigens, Differentiation; CD8-Positive T-Lymphocytes; CTLA-4 Antigen; Erythrocytes; Interferon-gamma; Lymphocyte Activation; Malaria, Cerebral; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/165409
• Institution: National University of Singapore

10.1371/journal.ppat.1002504