Enhancing specific disruption of intracellular protein complexes by hydrocarbon stapled peptides using lipid based delivery

• Main Authors: Thean, D, Ebo, J.S, Luxton, T, Lee, X.C, Yuen, T.Y, Ferrer, F.J, Johannes, C.W, Lane, D.P, Brown, C.J
• Other Authors: MEDICINE
• Format: Article
• Published: 2020
• Subjects: cation; hydrocarbon; lipid; multiprotein complex; peptide; protein MDM2; protein p53; pyridine derivative; cell survival; chemistry; drug delivery system; endosome; genetics; HEK293 cell line; human; IC50; intracellular space; metabolism; peptide library; reporter gene; transcription initiation; Cations; Cell Survival; Drug Delivery Systems; Endosomes; Genes, Reporter; HEK293 Cells; Humans; Hydrocarbons; Inhibitory Concentration 50; Intracellular Space; Lipids; Multiprotein Complexes; Peptide Library; Peptides; Proto-Oncogene Proteins c-mdm2; Pyridines; Transcriptional Activation; Tumor Suppressor Protein p53
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/178325
• Institution: National University of Singapore

10.1038/s41598-017-01712-5