Reactive metabolite-induced protein glutathionylation: a potentially novel mechanism underlying acetaminophen hepatotoxicity

by Chan, James Chun Yip, Soh, Alex Cheow Khoon, Kioh, Dorinda Yan Qin, Li, Jianguo, Verma, Chandra, Koh, Siew Kwan, Beuerman, Roger Wilmer, Zhou, Lei, Chan, Eric Chun Yong
Published 2018

Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein–protein interaction

by Iegre, Jessica, Brear, Paul, Baker, David J., Tan, Yaw Sing, Atkinson, Eleanor L., Sore, Hannah F., O' Donovan, Daniel H., Hyvönen, Marko, Spring, David R., Verma, Chandra Shekhar
Published 2019

Designer co-beta-peptide copolymer selectively targets resistant and biofilm Gram-negative bacteria

by Si. Zhangyong, Li, Jianguo, Ruan, Lin, Reghu, Sheethal, Ooi, Ying Jie, Li, Peng, Zhu, Yabin, Hammond, Paula T., Verma, Chandra S., Bazan, Guillermo C., Pethe, Kevin, Chan-Park, Mary B.
Published 2023

Reactive Metabolite-induced Protein Glutathionylation: A Potentially Novel Mechanism Underlying Acetaminophen Hepatotoxicity

by Chan, James Chun Yip, Soh, Alex Cheow Khoon, Kioh, Dorinda Yan Qin, Li, Jianguo, Verma, Chandra, Koh, Siew Kwan, Beuerman, Roger Wilmer, Zhou, Lei, Chan, Eric Chun Yong
Published 2020

How well does molecular simulation reproduce environment-specific conformations of the intrinsically disordered peptides PLP, TP2 and ONEG?

by Reid, Lauren M., Guzzetti, Ileana, Svensson, Tor, Carlsson, Anna-Carin, Su, Wu, Leek, Tomas, von Sydow, Lena, Czechtizky, Werngard, Miljak, Marija, Verma, Chandra, De Maria, Leonardo, Essex, Jonathan W.
Published 2022

Design and evaluation of tadpole-like conformational antimicrobial peptides

by Tang, Ziyi, Jiang, Wuqiao, Li, Shuangli, Huang, Xue, Yang, Yi, Chen, Xiaorong, Qiu, Jingyi, Xiao, Chuyu, Xie, Ying, Zhang, Xu, Li, Jianguo, Verma, Chandra Shekhar, He, Yun, Yang, Aimin
Published 2024

Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell

by Chattopadhyay, Anasuya, O’Connor, Cornelius J., Zhang, Fengzhi, Galvagnion, Celine, Galloway, Warren R. J. D., Tan, Yaw Sing, Stokes, Jamie E., Rahman, Taufiq, Verma, Chandra, Spring, David R., Itzhaki, Laura S.
Published 2018

Probing the Binding Mechanism of Mnk Inhibitors by Docking and Molecular Dynamics Simulations

by Kannan, Srinivasaraghavan, Poulsen, Anders, Yang, Hai Yan, Ho, Melvyn, Ang, Shi Hua, Eldwin, Tan Sum Wai, Jeyaraj, Duraiswamy Athisayamani, Chennamaneni, Lohitha Rao, Liu, Boping, Hill, Jeffrey, Verma, Chandra Shekhar, Nacro, Kassoum
Published 2016

Probing the binding mechanism of Mnk inhibitors by docking and molecular dynamics simulations

by Kannan, Srinivasaraghavan, Poulsen, Anders, Yang, Haiyan, Ho, Melvyn, Ang, Shihua, Eldwin, Tan Sum Wai Wai, Jeyaraj, Duraiswamy Athisayamani Thisayamani, Chennamaneni, Lohitha Rao Ao, Liu, Boping, Hill, Jeffrey, Verma, Chandra, Nacro, Kassoum
Published 2016

Molecular basis of dengue virus serotype 2 morphological switch from 29°C to 37°C

by Lim, Xin-Ni, Shan, Chao, Marzinek, Jan K., Dong, Hongping, Ng, Thiam Seng, Ooi, Justin Seng Geap, Fibriansah, Guntur, Wang, Jiaqi, Verma, Chandra Shekhar, Bond, Peter John, Shi, Pei-Yong, Lok, Shee-mei
Published 2020

Increased Protein S-Glutathionylation in Leber's Hereditary Optic Neuropathy (LHON)

by Zhou, Lei, Chan, James Chun Yip, Chupin, Stephanie, Gueguen, Naig, Desquiret-Dumas, Valerie, Koh, Siew Kwan, Li, Jianguo, Gao, Yan, Deng, Lu, Verma, Chandra, Beuerman, Roger W, Chan, Eric Chun Yong, Milea, Dan, Reynier, Pascal
Published 2020

Increased protein S-glutathionylation in Leber’s hereditary optic neuropathy (LHON)

by Zhou, Lei, Chan, James Chun Yip, Chupin, Stephanie, Gueguen, Naïg, Desquiret-Dumas, Valérie, Koh, Siew Kwan, Li, Jianguo, Gao, Yan, Deng, Lu, Verma, Chandra Shekhar, Beuerman, Roger W., Chan, Eric Chun Yong, Milea, Dan, Reynier, Pascal
Published 2021

The p53–Mdm2 interaction and the E3 ligase activity of Mdm2/Mdm4 are conserved from lampreys to humans

by Venkatesh, Byrappa, Lane, David P., Coffill, Cynthia R., Lee, Alison P., Siau, Jia Wei, Chee, Sharon M., Joseph, Thomas L., Tan, Yaw Sing, Madhumalar, Arumugam, Tay, Boon-Hui, Brenner, Sydney, Verma, Chandra Shekhar, Ghadessy, Farid J.
Published 2016

Synthetic multivalent antifungal peptides effective against fungi

by Lakshminarayanan, Rajamani, Liu, Shouping, Li, Jianguo, Nandhakumar, Muruganantham, Aung, Thet Tun, Goh, Eunice, Chang, Jamie Ya Ting, Saraswathi, Padhmanaban, Tang, Charles, Safie, Siti Radiah Binte, Lin, Lim Yih, Riezman, Howard, Lei, Zhou, Verma, Chandra S., Beuerman, Roger W.
Published 2014

Stapled peptides as a new technology to investigate protein–protein interactions in human platelets

by Iegre, Jessica, Ahmed, Niaz S., Gaynord, Josephine S., Wu, Yuteng, Herlihy, Kara M., Tan, Yaw Sing, Lopes-Pires, Maria E., Jha, Rupam, Lau, Yu Heng, Sore, Hannah F., Verma, Chandra, O' Donovan, Daniel H., Pugh, Nicholas, Spring, David R.
Published 2018

Mechanism of enhanced immature dengue virus attachment to endosomal membrane induced by prM antibody

by Wirawan, Melissa, Fibriansah, Guntur, Marzinek, Jan K., Lim, Xin Xiang, Ng, Thiam-Seng, Sim, Adelene Y. L., Zhang, Qian, Kostyuchenko, Victor A., Shi, Jian, Smith, Scott A., Verma, Chandra Shekhar, Anand, Ganesh, Crowe, James E., Bond, Peter J., Lok, Shee-Mei
Published 2021

Insight into membrane selectivity of linear and branched polyethylenimines and their potential as biocides for advanced wound dressings

by Fox, Stephen John, Fazil, Mobashar Hussain Urf Turabe, Dhand, Chetna, Venkatesh, Mayandi, Goh, Eunice Tze Leng, Harini, Sriram, Eugene, Christo, Lim, Rayne Rui, Ramakrishna, Seeram, Chaurasia, Shyam Sunder, Beuerman, Roger W., Verma, Chandra Shekhar, Verma, Navin Kumar, Loh, Xian Jun, Lakshminarayanan, Rajamani
Published 2016

Functionalised staple linkages for modulating the cellular activity of stapled peptides

by Lau, Yu Heng, de Andrade, Peterson, Quah, Soo-Tng, Rossmann, Maxim, Laraia, Luca, Sköld, Niklas, Sum, Tze Jing, Rowling, Pamela J. E., Joseph, Thomas L., Verma, Chandra, Hyvönen, Marko, Itzhaki, Laura S., Venkitaraman, Ashok R., Brown, Christopher J., Lane, David P., Spring, David R.
Published 2016

Decreased GLUT2 and glucose uptake contribute to insulin secretion defects in MODY3/HNF1A hiPSC-derived mutant ? cells

by Low, Blaise Su Jun, Lim, Chang Siang, Ding, Shirley Suet Lee, Tan, Yaw Sing, Ng, Natasha Hui Jin, Krishnan, Vidhya Gomathi, Ang, Su Fen, Neo, Claire Wen Ying, Verma, Chandra S., Hoon, Shawn, Lim, Su Chi, Tai, E. Shyong, Teo, Adrian Kee Keong
Published 2022

Dephosphorylation of YB-1 is required for nuclear localisation during G2 phase of the cell cycle

by Mehta, Sunali, McKinney, Cushla, Algie, Michael, Verma, Chandra Shekhar, Kannan, Srinivasaraghavan, Harfoot, Rhodri, Bartolec, Tara K., Bhatia, Puja, Fisher, Alistair J., Gould, Maree L., Parker, Kim, Cesare, Anthony J., Cunliffe, Heather E., Cohen, Scott B., Kleffmann, Torsten, Braithwaite, Antony W., Woolley, Adele G.
Published 2021