Differential cytokine responses in hospitalized COVID-19 patients limit efficacy of Remdesivir

by Chan, Yi-Hao, Young, Barnaby Edward, Fong, Siew-Wai, Ding, Ying, Goh, Yun Shan, Chee, Rhonda Sin-Ling, Tan, Seow-Yen, Kalimuddin, Shirin, Tambyah, Paul A., Leo, Yee Sin, Ng, Lisa F. P., Lye, David C., Renia, Laurent
Published 2022

Malaria abrogates O'nyong-nyong virus pathologies by restricting virus infection in nonimmune cells

by Torres-Ruesta, Anthony, Teo, Teck-Hui, Chan, Yi-Hao, Siti Naqiah Amrun, Yeo, Nicholas Kim-Wah, Lee, Cheryl Yi-Pin, Nguee, Samantha Yee-Teng, Tay, Matthew Zirui, Nosten, Francois, Fong, Siew-Wai, Lum, Fok-Moon, Carissimo, Guillaume, Renia, Laurent, Ng, Lisa F. P.
Published 2023

Relative deficiency in interferon-γ-secreting CD4+T cells is strongly associated with poorer COVID-19 vaccination responses in older adults

by Ho, Vanda WT, Boon, Low Heng, Cui, Jianzhou, Juequn, Zhou, Shunmuganathan, Bhuvaneshwari, Gupta, Rashi, Tan, Nikki YJ, Qian, Xinlei, Purushotorman, Kiren, Fong, Siew-Wai, Renia, Laurent, Ng, Lisa FP, Angeli, Veronique, Chen, Jinmiao, Kennedy, Brian K, Ong, Catherine WM, Macary, Paul A
Published 2024

Relative deficiency in interferon-γ-secreting CD4+ T cells is strongly associated with poorer COVID-19 vaccination responses in older adults

by Ho, Vanda W. T., Boon, Low Heng, Cui, Jianzhou, Juequn, Zhou, Shunmuganathan, Bhuvaneshwari, Gupta, Rashi, Tan, Nikki Y. J., Qian, Xinlei, Purushotorman, Kiren, Fong, Siew-Wai, Renia, Laurent, Ng, Lisa F. P., Angeli, Veronique, Chen, Jinmiao, Kennedy, Brian K., Ong, Catherine W. M., Macary, Paul A.
Published 2024

Persistent symptoms and association with inflammatory cytokine signatures in recovered coronavirus disease 2019 patients

by Ong, Sean Wei Xiang, Fong, Siew-Wai, Young, Barnaby Edward, Chan, Yi-Hao, Lee, Bernett, Siti Naqiah Amrun, Chee, Rhonda Sin-Ling, Yeo, Nicholas Kim-Wah, Tambyah, Paul, Pada, Surinder, Tan, Seow Yen, Ding, Ying, Renia, Laurent, Leo, Yee Sin, Ng, Lisa F. P., Lye, David C.
Published 2022

Persistent Symptoms and Association With Inflammatory Cytokine Signatures in Recovered Coronavirus Disease 2019 Patients.

by Ong, Sean Wei Xiang, Fong, Siew-Wai, Young, Barnaby Edward, Chan, Yi-Hao, Lee, Bernett, Amrun, Siti Naqiah, Chee, Rhonda Sin-Ling, Yeo, Nicholas Kim-Wah, Tambyah, Paul, Pada, Surinder, Tan, Seow Yen, Ding, Ying, Renia, Laurent, Leo, Yee-Sin, Ng, Lisa FP, Lye, David Chien
Published 2021

Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation

by Chioh, Florence WJ, Fong, Siew-Wai, Young, Barnaby E, Wu, Kan-Xing, Siau, Anthony, Krishnan, Shuba, Chan, Yi-Hao, Carissimo, Guillaume, Teo, Louis LY, Gao, Fei, Tan, Ru San, Zhong, Liang, Koh, Angela S, Tan, Seow-Yen, Tambyah, Paul A, Renia, Laurent, Ng, Lisa FP, Lye, David C, Cheung, Christine
Published 2022

Conserved longitudinal alterations of anti-S-protein IgG subclasses in disease progression in initial ancestral Wuhan and vaccine breakthrough Delta infections

by Goh, Yun Shan, Fong, Siew-Wai, Hor, Pei Xiang, Siti Naqiah Amrun, Lee, Cheryl Yi-Pin, Young, Barnaby Edward, Chia, Po Ying, Tambyah, Paul A., Kalimuddin, Shirin, Pada, Surinder, Tan, Seow-Yen, Sun, Louisa Jin, Chen, Mark I-Cheng, Leo, Yee-Sin, Lye, David C., Ng, Lisa F. P., Renia, Laurent
Published 2023

Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation

by Chioh, Florence Wen Jing, Fong, Siew-Wai, Young, Barnaby Edward, Wu, Kan Xing, Siau, Anthony, Krishnan, Shuba, Chan, Yi-Hao, Carissimo, Guillaume, Teo, Louis L. Y., Gao, Fei, Tan, Ru San, Zhong, Liang, Koh, Angela S., Tan, Seow-Yen, Tambyah, Paul A., Renia, Laurent, Ng, Lisa F. P., Lye, David C., Cheung, Christine
Published 2021

Resistance of SARS-CoV-2 variants to neutralization by convalescent plasma from early COVID-19 outbreak in Singapore

by Wang, Bei, Goh, Yun Shan, Prince, Tessa, Ngoh, Eve Zi Xian, Salleh, Siti Nazihah Mohd, Hor, Pei Xiang, Loh, Chiew Yee, Fong, Siew Wai, Hartley, Catherine, Tan, Seow-Yen, Young, Barnaby Edward, Leo, Yee-Sin, Lye, David C., Maurer-Stroh, Sebastian, Ng, Lisa F. P., Hiscox, Julian A., Renia, Laurent, Wang, Cheng-, I
Published 2022

Resistance of SARS-CoV-2 variants to neutralization by convalescent plasma from early COVID-19 outbreak in Singapore

by Wang, Bei, Goh, Yun Shan, Prince, Tessa, Ngoh, Eve Zi Xian, Salleh, Siti Nazihah Mohd, Hor, Pei Xiang, Loh, Chiew Yee, Fong, Siew Wai, Hartley, Catherine, Tan, Seow-Yen, Young, Barnaby Edward, Leo, Yee Sin, Lye, David Chien Boon, Maurer-Stroh, Sebastian, Ng, Lisa F. P., Hiscox, Julian A., Renia, Laurent, Wang, Cheng-I
Published 2021

Prolonged inflammation in patients hospitalized for coronavirus disease 2019 (COVID-19) resolves 2 years after infection

by Fong, Siew-Wai, Goh, Yun Shan, Torres-Ruesta, Anthony, Chang, Zi Wei, Chan, Yi-Hao, Neo, Vanessa Kexin, Lee, Bernett, Duan, Kaibo, Amrun, Siti Naqiah, Yeo, Nicholas Kim-Wah, Chen, Hsiuyi V., Tay, Matthew Zirui, Carissimo, Guillaume, Tan, Seow Yen, Leo, Yee Sin, Lye, David C., Renia, Laurent, Young, Barnaby Edward, Ng, Lisa F. P.
Published 2023

Longitudinal single cell atlas identifies complex temporal relationship between type I interferon response and COVID-19 severity

by Lin, Quy Xiao Xuan, Rajagopalan, Deepa, Gamage, Akshamal M., Tan, Le Min, Venkatesh, Prasanna Nori, Chan, Wharton O. Y., Kumar, Dilip, Agrawal, Ragini, Chen, Yao, Fong, Siew-Wai, Singh, Amit, Sun, Louisa J., Tan, Seow-Yen, Chai, Louis Yi Ann, Somani, Jyoti, Lee, Bernett, Renia, Laurent, Ng, Lisa F. P., Ramanathan, Kollengode, Wang, Lin-Fa, Young, Barnaby, Lye, David, Singhal, Amit, Prabhakar, Shyam
Published 2024

Imprinting of IgA responses in previously infected individuals receiving bivalent mRNA vaccines (WT and BA.4/BA.5 or WT and BA.1)

by Goh, Yun Shan, Fong, Siew-Wai, Hor, Pei Xiang, Loh, Chiew Yee, Tay, Matthew Zirui, Wang, Bei, Salleh, Siti Nazihah Mohd, Ngoh, Eve Zi Xian, Lee, Raphael Tze Chuen, Poh, Xuan Ying, Lee, I. Russel, Rao, Suma, Chia, Po Ying, Maurer-Stroh, Sebastian, Wang, Cheng-I, Leo, Yee Sin, Lye, David C., Young, Barnaby Edward, Ng, Lisa F. P., Renia, Laurent
Published 2024

Higher Delta variant-specific neutralizing antibodies prevented infection in close contacts vaccinated with ancestral mRNA vaccines during the SARS-CoV-2 Delta wave

by Goh, Yun Shan, Fong, Siew-Wai, Tay, Matthew Zirui, Rouers, Angeline, Chang, Zi Wei, Chavatte, Jean-Marc, Hor, Pei Xiang, Loh, Chiew Yee, Huang, Yuling, Tan, Yong Jie, Wang, Bei, Ngoh, Eve Zi Xian, Siti Nazihah Mohd Salleh, Lee, Raphael Tze Chuen, Lim, Georgina, Maurer-Stroh, Sebastian, Wang, Cheng-I, Leo, Yee-Sin, Lin, Raymond T. P., Lam, Meng Chon, Lye, David C., Young, Barnaby Edward, Ng, Lisa F. P., Renia, Laurent
Published 2024

Linear B-cell epitopes in the spike and nucleocapsid proteins as markers of SARS-CoV-2 exposure and disease severity

by Siti Naqiah Amrun, Lee, Cheryl Yi-Pin, Lee, Bernett, Fong, Siew-Wai, Young, Barnaby Edward, Chee, Rhonda Sin-Ling, Yeo, Nicholas Kim-Wah, Torres-Ruesta, Anthony, Carissimo, Guillaume, Poh, Chek Meng, Chang, Zi Wei, Tay, Matthew Zirui, Chan, Yi-Hao, Chen, Mark I-Cheng, Low, Jenny Guek-Hong, Tambyah, Paul A., Kalimuddin, Shirin, Pada, Surinder, Tan, Seow-Yen, Sun, Louisa Jin, Leo, Yee-Sin, Lye, David C., Renia, Laurent, Ng, Lisa F. P.
Published 2020

Association of SARS-CoV-2 clades with clinical, inflammatory and virologic outcomes: an observational study

by Young, Barnaby Edward, Wei, Wycliffe E., Fong, Siew-Wai, Mak, Tze-Minn, Anderson, Danielle E., Chan, Yi-Hao, Pung, Rachael, Heng, Cheryl S. Y., Ang, Li Wei, Zheng, Adrian Kang Eng, Lee, Bernett, Kalimuddin, Shirin, Pada, Surinder, Tambyah, Paul A., Parthasarathy, Purnima, Tan, Seow Yen, Sun, Louisa, Smith, Gavin J. D., Lin, Raymond Tzer Pin, Leo, Yee Sin, Renia, Laurent, Wang, Lin-Fa, Ng, Lisa F. P., Maurer-Stroh, Sebastian, Lye, David C., Lee, Vernon J.
Published 2022

Association of SARS-CoV-2 clades with clinical, inflammatory and virologic outcomes: An observational study

by Young, Barnaby E, Wei, Wycliffe E, Fong, Siew-Wai, Mak, Tze-Minn, Anderson, Danielle E, Chan, Yi-Hao, Pung, Rachael, Heng, Cheryl SY, Ang, Li Wei, Zheng, Adrian Kang Eng, Lee, Bernett, Kalimuddin, Shirin, Pada, Surinder, Tambyah, Paul A, Parthasarathy, Purnima, Tan, Seow Yen, Sun, Louisa, Smith, Gavin JD, Lin, Raymond Tzer Pin, Leo, Yee-Sin, Renia, Laurent, Wang, Lin-Fa, Ng, Lisa FP, Maurer-Stroh, Sebastian, Lye, David Chien, Lee, Vernon J
Published 2021

Asymptomatic COVID-19: disease tolerance with efficient anti-viral immunity against SARS-CoV-2

by Chan, Yi-Hao, Fong, Siew-Wai, Poh, Chek-Meng, Carissimo, Guillaume, Yeo, Nicholas Kim-Wah, Amrun, Siti Naqiah, Goh, Yun Shan, Lim, Jackwee, Xu, Weili, Chee, Rhonda Sin-Ling, Torres-Ruesta, Anthony, Lee, Cheryl Yi-Pin, Tay, Matthew Zirui, Chang, Zi Wei, Lee, Wen-Hsin, Wang, Bei, Tan, Seow-Yen, Kalimuddin, Shirin, Young, Barnaby Edward, Leo, Yee-Sin, Wang, Cheng-, I, Lee, Bernett, Rötzschke, Olaf, Lye, David Chien, Renia, Laurent, Ng, Lisa F. P.
Published 2022

Waning of specific antibodies against Delta and Omicron variants five months after a third dose of BNT162b2 SARS-CoV-2 vaccine in elderly individuals

by Goh, Yun Shan, Rouers, Angeline, Fong, Siew-Wai, Zhuo, Nicole Ziyi, Hor, Pei Xiang, Loh, Chiew Yee, Huang, Yuling, Neo, Vanessa Kexin, Kam, Isaac Kai Jie, Wang, Bei, Ngoh, Eve Zi Xian, Salleh, Siti Nazihah Mohd, Lee, Raphael Tze Chuen, Pada, Surinder, Sun, Louisa Jin, Ong, Desmond Luan Seng, Somani, Jyoti, Lee, Eng Sing, Maurer-Stroh, Sebastian, Wang, Cheng-I., Leo, Yee Sin, Ren, Ee Chee, Lye, David C., Young, Barnaby Edward, Ng, Lisa F. P., Renia, Laurent
Published 2023