Development of bioinformatics methods and platforms to characterize chromatin interactions

Development of bioinformatics methods and platforms to characterize chromatin interactions

Chromatin interactions are loops between genomic elements, such as enhancers and promoters, that regulate gene transcription. High throughput chromosome conformation capture (Hi-C) is an important method for studying chromatin interactions in the whole genome. Our aim is to understand or address the...

Saved in:

書目詳細資料
主要作者:	Chen, Kaijing
其他作者:	Melissa Jane Fullwood
格式:	Thesis-Doctor of Philosophy
語言:	English
出版:	Nanyang Technological University 2024
主題:	Medicine, Health and Life Sciences Chromatin interaction Super-silencer Cancer
在線閱讀:	https://hdl.handle.net/10356/177337
標簽:	添加標簽沒有標簽, 成為第一個標記此記錄!

相似書籍

Characterizing the interplay between super enhancers and chromatin interactions in cancer
由: Choudhary, Ruchi
出版: (2024)

H3K27ME3-RICH GENOMIC REGIONS CAN FUNCTION AS SILENCERS TO REPRESS GENE EXPRESSION VIA CHROMATIN INTERACTIONS
由: CAI YICHAO
出版: (2020)

Super-silencer perturbation by EZH2 and REST inhibition leads to large loss of chromatin interactions and reduction in cancer growth
由: Zhang, Ying, et al.
出版: (2024)

Long-distance repression by human silencers: chromatin interactions and phase separation in silencers
由: Zhang, Ying, et al.
出版: (2022)

Chromatin interactions and regulatory elements in cancer : from bench to bedside
由: See, Yi Xiang, et al.
出版: (2020)

3D GENOME ORGANIZATION UNDERLIES SYNERGISM BETWEEN SILENCERS
由: ZHANG YING
出版: (2021)

MYC overexpression leads to increased chromatin interactions at superenhancers and MYC binding sites
由: See, Yi Xiang, et al.
出版: (2022)

Chromatin interaction networks and higher order architectures of eukaryotic genomes
由: Singh Sandhu, K., et al.
出版: (2013)

H3K27me3-rich genomic regions can function as silencers to repress gene expression via chromatin interactions
由: Cai, Yichao, et al.
出版: (2021)

CHARACTERIZING FUNCTIONAL ROLES AND CLINICAL IMPLICATIONS OF SUPER ENHANCER ASSOCIATED GENES IN MULTIPLE MYELOMA
由: XIONG SINAN
出版: (2024)

ChIP-based methods for the identification of long-range chromatin interactions
由: Fullwood, M.J., et al.
出版: (2014)

The shelterin component TRF2 mediates columnar stacking of human telomeric chromatin
由: Wong, Sook Yi, et al.
出版: (2024)

Super-enhancers, phase-separated condensates, and 3D genome organization in cancer
由: Tang, Seng Chuan, et al.
出版: (2023)

Exploration of explainable artificial intelligence methods on chromatin interactions neural network
由: Tan, Caken
出版: (2024)

Deep learning to predict chromatin interactions from RNA-Seq data
由: Tan, Wei Kit
出版: (2024)

AP-2γ 3 regulates oestrogen receptor-mediated long-range chromatin interaction and gene transcription
由: Tan, S.K., et al.
出版: (2013)

Chromatin interaction analysis with Paired-End Tag Sequencing (ChIA-PET) for mapping chromatin Interactions and Understanding Transcription Regulation
由: Goh, Y., et al.
出版: (2014)

Nucleosome hopping and sliding kinetics determined from dynamics of single chromatin fibers in Xenopus egg extracts
由: Ranjith, P., et al.
出版: (2014)

Single-molecule force spectroscopy on histone H4 tail-cross-linked chromatin reveals fiber folding
由: Kaczmarczyk, Artur, et al.
出版: (2018)

Allosteric cross-talk in chromatin can mediate drug-drug synergy
由: Adhireksan, Zenita, et al.
出版: (2018)

Paired-End Tags For Unravelling Genomic Elements And Chromantin Interactions
由: MELISSA JANE FULLWOOD
出版: (2011)

Single-molecule compaction of megabase-long chromatin molecules by multivalent cations
由: Zinchenko, Anatoly, et al.
出版: (2018)

CRYO-ELECTRON TOMOGRAPHY STUDIES OF EUKARYOTIC CHROMATIN ORGANISATION AT MOLECULAR LEVEL
由: CAI SHUJUN
出版: (2018)

High-resolution RNA allelotyping along the inactive X chromosome: evidence of RNA polymerase III in regulating chromatin configuration
由: Hong, Ru, et al.
出版: (2017)

GenomicInteractions: An R/Bioconductor package for manipulating and investigating chromatin interaction data
由: Harmston, N, et al.
出版: (2020)

Studies of mammalian sperm membrane molecules involving in fertilization and chromatin organization during spermatogenesis
由: Wattana Weerachatyanukul
出版: (2023)

Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation
由: Davey, Gabriela Elzbieta, et al.
出版: (2018)

Interaction of SIRT6 with telomeric chromatin in the context of ageing and cancer
由: Teh, Zhi Jing
出版: (2024)

ROLE OF COMPRESSIVE FORCE IN ALTERING CHROMATIN CONDENSATION AND ITS APPLICATION FOR CANCER DIAGNOSIS
由: KARTHIK DAMODARAN
出版: (2018)

Chromatin interaction neural network (ChINN): a machine learning-based method for predicting chromatin interactions from DNA sequences
由: Cao, Fan, et al.
出版: (2021)

ROLE OF CELL GEOMETRY AND CHROMATIN ARCHITECTURE IN MODULATING CELLULAR RESPONSE TO ENVIRONMENTAL STIMULI
由: SARADHA VENKATACHALAPATHY
出版: (2021)

Interaction of TRF2-Rap1 with telomeric chromatin in the context of aging and cancer
由: Woo, Jia Qi
出版: (2024)

Chromatin immunoprecipitation in skeletal myoblasts
由: Rao, VK, et al.
出版: (2019)

Reconstituted TAD-size chromatin fibers feature heterogeneous nucleosome clusters
由: Korolev, Nikolay, et al.
出版: (2023)

Spermatogenesis and chromatin organization in the male germ cells of Rana Tigerina
由: Sirikul Manochantr
出版: (2023)

Engineering nucleosomes for generating diverse chromatin assemblies
由: Adhireksan, Zenita, et al.
出版: (2021)

Chromatin regulation of flowering
由: He, Y.
出版: (2014)

Control of the transition to flowering by chromatin modifications
由: He, Y.
出版: (2014)

Chromatin regulation landscape of embryonic stem cell identity
由: Lee, Y.H., et al.
出版: (2014)

Bioinformatics investigations on multi-omics datasets of neurodegeneration
由: Lim, Jolyn Jia Jia
出版: (2023)