Enantioselective transformation of hydrazones via remote NHC catalysis: activation across C=N and N−N bonds

• Main Authors: Jin, Jiamiao, Lv, Ya, Tang, Wenli, Teng, Kunpeng, Huang, Yixian, Ding, Jingxin, Li, Tingting, Wang, Guanjie, Chi, Robin Yonggui
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2025
• Subjects: Chemistry; Chiral heterocyclic molecule; Enantioselective transformation
• Online Access: https://hdl.handle.net/10356/182311
• Institution: Nanyang Technological University

The catalytic asymmetric transformation of nitrogen atoms to prepare heterocyclic molecules is of significant value in organic synthesis and biological applications. Here, we disclose the activation of the nitrogen atom in hydrazine-derived hydrazone via an N-heterocyclic carbene (NHC) organic catal...