Biotin analogues with antibacterial activity are potent inhibitors of biotin protein ligase

• Main Authors: Tieu, William, Zvarec, Ondrej, Bell, Jan M., Turnidge, John D., Wallace, John C., Soares da Costa, Tatiana P., Yap, Min Y., Booker, Grant W., Wilce, Matthew C. J., Abell, Andrew D., Polyak, Steven W.
• 其他作者: School of Materials Science & Engineering
• 格式: Article
• 語言: English
• 出版: 2013
• 在線閱讀: https://hdl.handle.net/10356/97854; http://hdl.handle.net/10220/12344
• 機構: Nanyang Technological University

There is a desperate need to develop new antibiotic agents to combat the rise of drug-resistant bacteria, such as clinically important Staphylococcus aureus. The essential multifunctional enzyme, biotin protein ligase (BPL), is one potential drug target for new antibiotics. We report the synthesis a...