Insights into the mechanism and regulation of pyruvate carboxylase by characterisation of a biotin-deficient mutant of the Bacillus thermodenitrificans enzyme
Pyruvate carboxylase is a biotin-dependent enzyme in which the biotin is carboxylated by a putative carboxyphosphate intermediate that is formed in a reaction between ATP and bicarbonate. The resultant carboxybiotin then transfers its carboxyl group to pyruvate to form oxaloacetate. In the Bacillus...
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Main Authors: | Abdussalam Adina-Zada, Sarawut Jitrapakdee, Kathy H. Surinya, Matthew J. McIldowie, Matthew J. Piggott, W. Wallace Cleland, John C. Wallace, Paul V. Attwood |
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Other Authors: | University of Western Australia |
Format: | Article |
Published: |
2018
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Subjects: | |
Online Access: | https://repository.li.mahidol.ac.th/handle/123456789/18988 |
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Institution: | Mahidol University |
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