Urokinase receptor is necessary for bacterial defense against pneumonia-derived septic melioidosis by facilitating phagocytosis

by W. Joost Wiersinga, Liesbeth M. Kager, Joppe W.R. Hovius, Gerritje J.W. Van Der Windt, Alex F. De Vos, Joost C.M. Meijers, Joris J. Roelofs, Arjen Dondorp, Marcel Levi, Nicholas P. Day, Sharon J. Peacock, Tom Van Der Poll
Published 2018

Trimethoprim-sulfamethoxazole versus trimethoprimsulfamethoxazole plus doxycycline as oral eradicative treatment for melioidosis (MERTH): A multicentre, double-blind, non-inferiori...

by Ploenchan Chetchotisakd, Wirongrong Chierakul, Wipada Chaowagul, Siriluck Anunnatsiri, Kriangsak Phimda, Piroon Mootsikapun, Seksan Chaisuksant, Jiraporn Pilaikul, Bandit Thinkhamrop, Sunchai Phiphitaporn, Wattanachai Susaengrat, Chalongchai Toondee, Surasakdi Wongrattanacheewin, Vanaporn Wuthiekanun, Narisara Chantratita, Janjira Thaipadungpanit, Nicholas P. Day, Direk Limmathurotsakul, Sharon J. Peacock
Published 2018

Genome sequencing defines phylogeny and spread of methicillin-resistant Staphylococcus aureus in a high transmission setting

by Steven Y.C. Tong, Matthew T.G. Holden, Emma K. Nickerson, Ben S. Cooper, Claudio U. Koser, Anne Cori, Thibaut Jombart, Simon Cauchemez, Christophe Fraser, Vanaporn Wuthiekanun, Janjira Thaipadungpanit, Maliwan Hongsuwan, Nicholas P. Day, Direk Limmathurotsakul, Julian Parkhill, Sharon J. Peacock
Published 2018

Toll-like receptor 2 impairs host defense in gram-negative sepsis caused by Burkholderia pseudomallei (Melioidosis)

by W. Joost Wiersinga, Catharina W. Wieland, Mark C. Dessing, Narisara Chantratita, Allen C. Cheng, Direk Limmathurotsakul, Wirongrong Chierakul, Masja Leendertse, Sandrine Florquin, Alex F. De Vos, Nicholas White, Arjen M. Dondorp, Nicholas P. Day, Sharon J. Peacock, Tom Van Der Poll
Published 2018

Comparison of glucose-6 phosphate dehydrogenase status by fluorescent spot test and rapid diagnostic test in Lao PDR and Cambodia NCT01872702 NCT

by Gisela Henriques, Koukeo Phommasone, Rupam Tripura, Thomas J. Peto, Shristi Raut, Coco Snethlage, Im Sambo, Nou Sanann, Chea Nguon, Bipin Adhikari, Tiengkham Pongvongsa, Mallika Imwong, Lorenz Von Seidlein, Nicholas P. Day, Nicholas J. White, Arjen M. Dondorp, Paul Newton, Benedikt Ley, Mayfong Mayxay
Published 2019

Pregnancy Outcome in Relation to Treatment of Murine Typhus and Scrub Typhus Infection: A Fever Cohort and a Case Series Analysis

by Rose McGready, John Antony Jude Prakash, Santosh Joseph Benjamin, Wanitda Watthanaworawit, Tippawan Anantatat, Ampai Tanganuchitcharnchai, Clare L. Ling, Saw Oo Tan, Elizabeth A. Ashley, Mupawjay Pimanpanarak, Stuart D. Blacksell, Nicholas P. Day, Pratap Singhasivanon, Nicholas J. White, François Nosten, Daniel H. Paris
Published 2018

Microvascular obstruction and endothelial activation are independently associated with the clinical manifestations of severe falciparum malaria in adults: An observational study

by Josh Hanson, Sue J. Lee, Amir M. Hossain, Nicholas M. Anstey, Prakaykaew Charunwatthana, Richard J. Maude, Hugh W. Kingston, Saroj K. Mishra, Sanjib Mohanty, Katherine Plewes, Kim Piera, Mahtab U. Hassan, Aniruddha Ghose, M. Aniruddha Faiz, Nicholas J. White, Nicholas P. Day, Arjen M. Dondorp
Published 2018

A Single Multilocus Sequence Typing (MLST) Scheme for Seven Pathogenic Leptospira Species

by Siriphan Boonsilp, Janjira Thaipadungpanit, Premjit Amornchai, Vanaporn Wuthiekanun, Mark S. Bailey, Matthew T G Holden, Cuicai Zhang, Xiugao Jiang, Nobuo Koizumi, Kyle Taylor, Renee Galloway, Alex R. Hoffmaster, Scott Craig, Lee D. Smythe, Rudy A. Hartskeerl, Nicholas P. Day, Narisara Chantratita, Edward J. Feil, David M. Aanensen, Brian G. Spratt, Sharon J. Peacock
Published 2018

Contribution of Functional Antimalarial Immunity to Measures of Parasite Clearance in Therapeutic Efficacy Studies of Artemisinin Derivatives

by Katherine O'Flaherty, Ricardo Ataíde, Sophie G. Zaloumis, Elizabeth A. Ashley, Rosanna Powell, Gaoqian Feng, Linda Reiling, Arjen M. Dondorp, Nicholas P. Day, Mehul Dhorda, Rick M. Fairhurst, Pharath Lim, Chanaki Amaratunga, Sasithon Pukrittayakamee, Tran Tinh Hien, Ye Htut, Mayfong Mayxay, M. Abul Faiz, James G. Beeson, Francois Nosten, Julie A. Simpson, Nicholas J. White, Freya J.I. Fowkes
Published 2020

Anti-Gametocyte Antigen Humoral Immunity and Gametocytemia During Treatment of Uncomplicated Falciparum Malaria: A Multi-National Study

by Katherine O’Flaherty, Jo Anne Chan, Julia C. Cutts, Sophie G. Zaloumis, Elizabeth A. Ashley, Aung Pyae Phyo, Damien R. Drew, Arjen M. Dondorp, Nicholas P. Day, Mehul Dhorda, Rick M. Fairhurst, Pharath Lim, Chanaki Amaratunga, Sasithon Pukrittayakamee, Tran Tinh Hien, Ye Htut, Mayfong Mayxay, M. Abul Faiz, Olugbenga A. Mokuolu, Marie A. Onyamboko, Caterina Fanello, Eizo Takashima, Takafumi Tsuboi, Michael Theisen, Francois Nosten, James G. Beeson, Julie A. Simpson, Nicholas J. White, Freya J.I. Fowkes
Published 2022

The diagnostic accuracy of three rapid diagnostic tests for typhoid fever at Chittagong Medical College Hospital, Chittagong, Bangladesh

by Rapeephan R. Maude, Hanna K. de Jong, Lalith Wijedoru, Masako Fukushima, Aniruddha Ghose, Rasheda Samad, Mohammed Amir Hossain, Mohammed Rezaul Karim, Mohammed Abul Faiz, Christopher M. Parry, Abdullah Abu Sayeed, Mahtab Uddin Hasan, Wirichada Pan-Ngum, Thomas W. van der Vaart, Asok Kumar Dutta, Nasir Uddin Mahmud, Murad Hero, Nafiz Iqbal, Zabeen Chaudhury, Tran Vu Thieu Nga, Pham Thanh Duy, Voong Vinh Phat, Richard J. Maude, Stephen Baker, W. Joost Wiersinga, Tom van der Poll, Nicholas P. Day, Arjen M. Dondorp
Published 2018

Improving the radical cure of vivax malaria (IMPROV): A study protocol for a multicentre randomised, placebo-controlled comparison of short and long course primaquine regimens

by Tesfay Abreha, Bereket Alemayehu, Ashenafi Assefa, Ghulam Rahim Awab, J. Kevin Baird, Beay Bezabih, Phaik Yeong Cheah, Nicholas P. Day, Angela Devine, Mehul Dorda, Arjen M. Dondorp, Samuel Girma, Tran Tinh Hien, Daddi Jima, Moges Kassa, Amha Kebende, Naw Htee Khu, Toby Leslie, Benedikt Ley, Yoel Lubell, Ismail Mayan, Zenebe Meaku, Ayodhia P. Pasaribu, Nguyen Hoan Phu, Ric N. Price, Julie A. Simpson, Hiwot Solomon, Inge Sutanto, Yehualahet Tadesse, Bob Taylor, Ngo Viet Thanh, Kamala Thriemer, Lorenz von Seidlein, Nicholas White, Adugna Woyessa, Prayoon Yuentrakul, Rohullah Zekria
Published 2018

Evolution and expansion of multidrug-resistant malaria in southeast Asia: a genomic epidemiology study

by William L. Hamilton, Roberto Amato, Rob W. van der Pluijm, Christopher G. Jacob, Huynh Hong Quang, Nguyen Thanh Thuy-Nhien, Tran Tinh Hien, Bouasy Hongvanthong, Keobouphaphone Chindavongsa, Mayfong Mayxay, Rekol Huy, Rithea Leang, Cheah Huch, Lek Dysoley, Chanaki Amaratunga, Seila Suon, Rick M. Fairhurst, Rupam Tripura, Thomas J. Peto, Yok Sovann, Podjanee Jittamala, Borimas Hanboonkunupakarn, Sasithon Pukrittayakamee, Nguyen Hoang Chau, Mallika Imwong, Mehul Dhorda, Ranitha Vongpromek, Xin Hui S. Chan, Richard J. Maude, Richard D. Pearson, T. Nguyen, Kirk Rockett, Eleanor Drury, Sónia Gonçalves, Nicholas J. White, Nicholas P. Day, Dominic P. Kwiatkowski, Arjen M. Dondorp, Olivo Miotto
Published 2020

Single low-dose primaquine for blocking transmission of Plasmodium falciparum malaria - a proposed model-derived age-based regimen for sub-Saharan Africa

by W. Robert Taylor, Htee Khu Naw, Kathryn Maitland, Thomas N. Williams, Melissa Kapulu, Umberto D'Alessandro, James A. Berkley, Philip Bejon, Joseph Okebe, Jane Achan, Alfred Ngwa Amambua, Muna Affara, Davis Nwakanma, Jean Pierre van Geertruyden, Muhindo Mavoko, Pascal Lutumba, Junior Matangila, Philipe Brasseur, Patrice Piola, Rindra Randremanana, Estrella Lasry, Caterina Fanello, Marie Onyamboko, Birgit Schramm, Zolia Yah, Joel Jones, Rick M. Fairhurst, Mahamadou Diakite, Grace Malenga, Malcolm Molyneux, Claude Rwagacondo, Charles Obonyo, Endalamaw Gadisa, Abraham Aseffa, Mores Loolpapit, Marie Claire Henry, Grant Dorsey, Chandy John, Sodiomon B. Sirima, Karen I. Barnes, Peter Kremsner, Nicholas P. Day, Nicholas J. White, Mavuto Mukaka
Published 2019

Genomic structure and diversity of Plasmodium falciparum in Southeast Asia reveal recent parasite migration patterns

by Amol C. Shetty, Christopher G. Jacob, Fang Huang, Yao Li, Sonia Agrawal, David L. Saunders, Chanthap Lon, Mark M. Fukuda, Pascal Ringwald, Elizabeth A. Ashley, Kay Thwe Han, Tin Maung Hlaing, Myaing M. Nyunt, Joana C. Silva, Kathleen E. Stewart, Christopher V. Plowe, Timothy D. O’Connor, Shannon Takala-Harrison, Harald Noedl, Wasif A. Khan, Paul Newton, Myat P. Kyaw, Nicholas J. White, Arjen M. Dondorp, Nicholas P. Day, Charles J. Woodrow, Mehul Dhorda, M. Abul Faiz, Rick M. Fairhurst, Pharath Lim, Rupam Tripura, Mayfong Mayxay, Ye Htut, Francois Nosten, Aung Pyae Phyo, Sasithon Pukrittayakamee, Tran Tinh Hien, Nguyen Thanh Thuy Nhien, Olugbenga A. Mokuolu, Caterina I. Fanello, Marie A. Onyamboko
Published 2020

Short-course primaquine for the radical cure of Plasmodium vivax malaria: a multicentre, randomised, placebo-controlled non-inferiority trial

by Walter R.J. Taylor, Kamala Thriemer, Lorenz von Seidlein, Prayoon Yuentrakul, Thanawat Assawariyathipat, Ashenafi Assefa, Sarah Auburn, Krisin Chand, Nguyen Hoang Chau, Phaik Yeong Cheah, Le Thanh Dong, Mehul Dhorda, Tamiru Shibru Degaga, Angela Devine, Lenny L. Ekawati, Fahmi Fahmi, Asrat Hailu, Mohammad Anwar Hasanzai, Tran Tinh Hien, Htee Khu, Benedikt Ley, Yoel Lubell, Jutta Marfurt, Hussein Mohammad, Kerryn A. Moore, Mohammad Nader Naddim, Ayodhia Pitaloka Pasaribu, Syahril Pasaribu, Cholrawee Promnarate, Awab Ghulam Rahim, Pasathron Sirithiranont, Hiwot Solomon, Herawati Sudoyo, Inge Sutanto, Ngo Viet Thanh, Nguyen Thi Tuyet-Trinh, Naomi Waithira, Adugna Woyessa, Fazal Yamin Yamin, Arjen Dondorp, Julie A. Simpson, J. Kevin Baird, Nicholas J. White, Nicholas P. Day, Ric N. Price
Published 2020

Baseline data of parasite clearance in patients with falciparum malaria treated with an artemisinin derivative: An individual patient data meta-analysis

by Salim Abdulla, Elizabeth A. Ashley, Quique Bassat, Delia Bethell, Anders Björkman, Steffen Borrmann, Umberto D’Alessandro, Prabin Dahal, Nicholas P. Day, Mahamadou Diakite, Abdoulaye A. Djimde, Arjen M. Dondorp, Socheat Duong, Michael D. Edstein, Rick M. Fairhurst, M. Abul Faiz, Catherine Falade, Jennifer A. Flegg, Carole Fogg, Raquel Gonzalez, Brian Greenwood, Philippe J. Guérin, Jean Paul Guthmann, Kamal Hamed, Tran Tinh Hien, Ye Htut, Elizabeth Juma, Pharath Lim, Andreas Mårtensson, Mayfong Mayxay, Olugbenga A. Mokuolu, Clarissa Moreira, Paul Newton, Harald Noedl, Francois Nosten, Bernhards R. Ogutu, Marie A. Onyamboko, Seth Owusu-Agyei, Aung Pyae Phyo, Zul Premji, Ric N. Price, Sasithon Pukrittayakamee, Michael Ramharter, Issaka Sagara, Youry Se, Seila Suon, Kasia Stepniewska, Stephen A. Ward, Nicholas J. White, Peter A. Winstanley
Published 2018

Genetic architecture of artemisinin-resistant Plasmodium falciparum

by Olivo Miotto, Roberto Amato, Elizabeth A. Ashley, Bronwyn Macinnis, Jacob Almagro-Garcia, Chanaki Amaratunga, Pharath Lim, Daniel Mead, Samuel O. Oyola, Mehul Dhorda, Mallika Imwong, Charles Woodrow, Magnus Manske, Jim Stalker, Eleanor Drury, Susana Campino, Lucas Amenga-Etego, Thuy Nhien Nguyen Thanh, Hien Tinh Tran, Pascal Ringwald, Delia Bethell, Francois Nosten, Aung Pyae Phyo, Sasithon Pukrittayakamee, Kesinee Chotivanich, Char Meng Chuor, Chea Nguon, Seila Suon, Sokunthea Sreng, Paul N. Newton, Mayfong Mayxay, Maniphone Khanthavong, Bouasy Hongvanthong, Ye Htut, Kay Thwe Han, Myat Phone Kyaw, Md Abul Faiz, Caterina I. Fanello, Marie Onyamboko, Olugbenga A. Mokuolu, Christopher G. Jacob, Shannon Takala-Harrison, Christopher V. Plowe, Nicholas P. Day, Arjen M. Dondorp, Chris C.A. Spencer, Gilean Mcvean, Rick M. Fairhurst, Nicholas J. White, Dominic P. Kwiatkowski
Published 2018

Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia

by Olivo Miotto, Jacob Almagro-Garcia, Magnus Manske, Bronwyn MacInnis, Susana Campino, Kirk A. Rockett, Chanaki Amaratunga, Pharath Lim, Seila Suon, Sokunthea Sreng, Jennifer M. Anderson, Socheat Duong, Chea Nguon, Char Meng Chuor, David Saunders, Youry Se, Chantap Lon, Mark M. Fukuda, Lucas Amenga-Etego, Abraham V.O. Hodgson, Victor Asoala, Mallika Imwong, Shannon Takala-Harrison, François Nosten, Xin Zhuan Su, Pascal Ringwald, Frédéric Ariey, Christiane Dolecek, Tran Tinh Hien, Maciej F. Boni, Cao Quang Thai, Alfred Amambua-Ngwa, David J. Conway, Abdoulaye A. Djimdé, Ogobara K. Doumbo, Issaka Zongo, Jean Bosco Ouedraogo, Daniel Alcock, Eleanor Drury, Sarah Auburn, Oliver Koch, Mandy Sanders, Christina Hubbart, Gareth Maslen, Valentin Ruano-Rubio, Dushyanth Jyothi, Alistair Miles, John O'Brien, Chris Gamble, Samuel O. Oyola, Julian C. Rayner, Chris I. Newbold, Matthew Berriman, Chris C.A. Spencer, Gilean McVean, Nicholas P. Day, Nicholas J. White, Delia Bethell, Arjen M. Dondorp, Christopher V. Plowe, Rick M. Fairhurst, Dominic P. Kwiatkowski
Published 2018

Genomic epidemiology of artemisinin resistant malaria

by Roberto Amato, Olivo Miotto, Charles J. Woodrow, Jacob Almagro-Garcia, Ipsita Sinha, Susana Campino, Daniel Mead, Eleanor Drury, Mihir Kekre, Mandy Sanders, Alfred Amambua-Ngwa, Chanaki Amaratunga, Lucas Amenga-Etego, Voahangy Andrianaranjaka, Tobias Apinjoh, Elizabeth Ashley, Sarah Auburn, Gordon A. Awandare, Vito Baraka, Alyssa Barry, Maciej F. Boni, Steffen Borrmann, Teun Bousema, Oralee Branch, Peter C. Bull, Kesinee Chotivanich, David J. Conway, Alister Craig, Nicholas P. Day, Abdoulaye Djimdé, Christiane Dolecek, Arjen M. Dondorp, Chris Drakeley, Patrick Duffy, Diego F. Echeverry, Thomas G. Egwang, Rick M. Fairhurst, Abul Faiz, Caterina I. Fanello, Tran Tinh Hien, Abraham Hodgson, Mallika Imwong, Deus Ishengoma, Pharath Lim, Chanthap Lon, Jutta Marfurt, Kevin Marsh, Mayfong Mayxay, Pascal Michon, Victor Mobegi, Olugbenga A. Mokuolu, Jacqui Montgomery, Ivo Mueller, Myat Phone Kyaw, Paul N. Newton, Francois Nosten, Rintis Noviyanti, Alexis Nzila, Harold Ocholla, Abraham Oduro, Marie Onyamboko, Jean Bosco Ouedraogo, Aung Pyae P. Phyo, Christopher Plowe, Ric N. Price, Sasithon Pukrittayakamee, Milijaona Randrianarivelojosia, Pascal Ringwald, Lastenia Ruiz, David Saunders, Alex Shayo, Peter Siba, Shannon Takala-Harrison, Thuy Nhien N. Thanh, Vandana Thathy, Federica Verra, Jason Wendler
Published 2018