Mapping the interactions between the NS4B and NS3 proteins of dengue virus

• Main Authors: Zou, Jing, Lee, Le Tian, Wang, Qing Yin, Xie, Xuping, Lu, Siyan, Yau, Yin Hoe, Yuan, Zhiming, Geifman Shochat, Susana, Kang, Congbao, Lescar, Julien, Shi, Pei-Yong
• Other Authors: Dermody, T. S.
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Microbiology::Virology
• Online Access: https://hdl.handle.net/10356/103132; http://hdl.handle.net/10220/25837
• Institution: Nanyang Technological University

Flavivirus RNA synthesis is mediated by a multiprotein complex associated with the endoplasmic reticulum membrane, named the replication complex (RC). Within the flavivirus RC, NS4B, an integral membrane protein with a role in virulence and regulation of the innate immune response, binds to the NS3...