A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage

• Main Authors: Shan, C, Muruato, A.E, Jagger, B.W, Richner, J, Nunes, B.T.D, Medeiros, D.B.A, Xie, X, Nunes, J.G.C, Morabito, K.M, Kong, W.-P, Pierson, T.C, Barrett, A.D, Weaver, S.C, Rossi, S.L, Vasconcelos, P.F.C, Graham, B.S, Diamond, M.S, Shi, P.-Y
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: live vaccine; neutralizing antibody; virus RNA; Zika virus vaccine; virus vaccine; abnormality; disease transmission; embryo; embryonic development; genome; immunization; infectious disease; male; nervous system disorder; pregnancy; primate; reproductive health; rodent; sexually transmitted disease; vaccine; virus; Zika virus disease; 3' untranslated region; adult; animal experiment; animal model; animal tissue; antibody blood level; antibody response; antibody titer; Article; comparative study; controlled study; female; fetus; fetus tissue; focus forming assay; gene deletion; limit of detection; maternal blood; mouse; nonhuman; oligospermia; orchitis; placenta tissue; rhesus monkey; single drug dose; spermatozoon count; spermatozoon motility; testis injury; vaccination; vaccine immunogenicity; vertical transmission; virus genome; virus load; virus replication; virus transmission; Zika fever; animal; C57BL mouse; genetics; immunology; pathology; preclinical study; prevention and control; testis; transmission; virology; Zika virus; Human immunodeficiency virus 1; Macaca mulatta; Mus; Primates; Animals; Drug Evaluation, Preclinical; Female; Infectious Disease Transmission, Vertical; Male; Mice; Mice, Inbred C57BL; Pregnancy; Testis; Vaccines, Attenuated; Viral Vaccines; Zika Virus; Zika Virus Infection
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/178574
• Institution: National University of Singapore

10.1038/s41467-017-00737-8