β-functionalization of carboxylic anhydrides with β-alkyl substituents through carbene organocatalysis

• Main Authors: Jin, Zhichao, Chen, Shaojin, Wang, Yuhuang, Zheng, Pengcheng, Yang, Song, Chi, Robin Yonggui
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Chemistry::Organic chemistry::Carbanions; DRNTU::Science::Chemistry::Physical chemistry::Catalysis
• Online Access: https://hdl.handle.net/10356/104027; http://hdl.handle.net/10220/24635
• Institution: Nanyang Technological University

The first NHC-catalyzed functionalization of carboxylic anhydrides is described. In this reaction, the β carbon behaves as a nucleophilic carbon and undergoes asymmetric reactions with electrophiles. Anhydrides with challenging β-alkyl substituents work effectively.