Antituberculosis activity of the antimalaria cytochrome bcc oxidase inhibitor SCR0911

• Main Authors: Chong, Sherilyn Shi Min, Manimekalai, Malathy Sony Subramanian, Sarathy, Jickky Palmae, Williams, Zoe C., Harold, Liam K., Cook, Gregory M., Dick, Thomas, Pethe, Kevin, Bates, Roderick Wayland, Grüber, Gerhard
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences::Biochemistry; Science::Biological sciences::Microbiology; Tuberculosis; Mycobacteria
• Online Access: https://hdl.handle.net/10356/138832
• Institution: Nanyang Technological University

The ability to respire and generate adenosine triphosphate (ATP) is essential for the physiology, persistence, and pathogenicity of Mycobacterium tuberculosis, which causes tuberculosis. By employing a lead repurposing strategy, the malarial cytochrome bc1 inhibitor SCR0911 was tested against mycoba...