Engineering protein theranostics using bio-orthogonal asparaginyl peptide ligases

• Main Authors: Wang, Zhen, Zhang, Dingpeng, Hemu, Xinya, Hu, Side, To, Janet, Zhang, Xiaohong, Lescar, Julien, Tam, James P., Liu, Chuan-Fa
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Biological sciences::Biochemistry; Protein Theranostics; Protein Labelling
• Online Access: https://hdl.handle.net/10356/148023
• Institution: Nanyang Technological University

Background: Protein theranostics integrate both diagnostic and treatment functions on a single disease-targeting protein. However, the preparation of these multimodal agents remains a major challenge. Ideally, conventional recombinant proteins should be used as starting materials for modification wi...