Carbene-catalyzed atroposelective synthesis of axially chiral styrenes

• Main Authors: Yan, Jia-Lei, Maiti, Rakesh, Ren, Shi-Chao, Tian, Weiyi, Li, Tingting, Xu, Jun, Mondal, Bivas, Jin, Zhichao, Chi, Robin Yonggui
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Chemistry; Acetylene; Alkene
• Online Access: https://hdl.handle.net/10356/155056
• Institution: Nanyang Technological University

Axially chiral styrenes bearing a chiral axis between a sterically non-congested acyclic alkene and an aryl ring are difficult to prepare due to low rotational barrier of the axis. Disclosed here is an N-heterocyclic carbene (NHC) catalytic asymmetric solution to this problem. Our reaction involves...