G4-PROTAC: targeted degradation of a G-quadruplex binding protein

G-quadruplex (G4)-binding proteins regulate important biological processes, but their interaction networks are poorly understood. We report the first use of G4 as warhead of a proteolysis-targeting chimera (G4-PROTAC) for targeted degradation of a G4-binding protein (RHAU/DHX36). G4-PROTAC provides...

Full description

Saved in:
Bibliographic Details
Main Authors: Patil, Kiran M., Chin, Danielle, Seah, Hui Ling, Shi, Qi, Lim, Kah Wai, Phan, Anh Tuân
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2022
Subjects:
Online Access:https://hdl.handle.net/10356/158329
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English

Similar Items