Nucleosomal DNA sequence-dependent properties, targeting by novel platinum-intercalator compounds, and interactions with the p53 transcription factor

DNA in the context of chromatin encodes the instructions for life, and in eukaryotic cells is packaged by histone proteins, together with other nuclear factors. The fundamental repeating unit of chromatin is the nucleosome, which packages DNA and regulates its accessibility by transacting factors. I...

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Bibliographic Details
Main Author: Chua, Eugene Yue Dao
Other Authors: Curtis Alexander Davey
Format: Theses and Dissertations
Language:English
Published: 2015
Subjects:
Online Access:http://hdl.handle.net/10356/62215
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Institution: Nanyang Technological University
Language: English

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