Facile access to chiral ketones through metal-free oxidative C-C bond cleavage of aldehydes by O2

• Main Authors: Tiwari, Bhoopendra, Zhang, Junming, Chi, Robin Yonggui
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2012
• Subjects: DRNTU::Engineering::Chemical engineering::Biochemical engineering
• Online Access: https://hdl.handle.net/10356/94646; http://hdl.handle.net/10220/8117
• Institution: Nanyang Technological University

Giving the metal the boot: The title reaction provides facile access to functionalized chiral ketones from chiral α,α′-disubstituted aldehydes in the presence of molecular oxygen (see scheme). The CC bond-cleavage approach offers an alternative or better method relative to the typical bond-forming s...