The flavivirus NS2B–NS3 protease–helicase as a target for antiviral drug development

by Luo, Dahai, Vasudevan, Subhash, Lescar, Julien
Published 2016

Expression and immunoaffinity purification of recombinant dengue virus 2 NS1 protein as a cleavable SUMOstar fusion

by Rozen-Gagnon, Kathryn, Ruedl, Christiane, Moreland, Nicole J., Vasudevan, Subhash G.
Published 2013

Zika virus nonstructural protein 5 residue R681 is critical for dimer formation and enzymatic activity

by Saw, Wuan-Geok, Chan, Kitti Wing-Ki, Vasudevan, Subhash G., Grüber, Gerhard
Published 2021

The magnitude of dengue virus NS1 protein secretion is strain dependent and does not correlate with severe pathologies in the mouse infection model

by Watanabe, Satoru, Tan, Kah Hin, Rathore, Abhay P. S., Rozen-Gagnon, Kathryn, Shuai, Wang, Ruedl, Christiane, Vasudevan, Subhash G.
Published 2013

Luteolin escape mutants of dengue virus map to prM and NS2B and reveal viral plasticity during maturation

by Vasudevan, Subhash G., Peng, Minhua, Swarbrick, Crystall Marie Dawn, Chan, Kitti Wing-Ki, Luo, Dahai, Zhang, Wei, Lai, Xiaoping, Li, Geng
Published 2019

Crystal structures of full length DENV4 NS2B-NS3 reveal the dynamic interaction between NS2B and NS3

by Phoo, Wint Wint, El Sahili, Abbas, Zhang, ZhenZhen, Chen, Ming Wei, Liew, Chong Wai, Lescar, Julien, Vasudevan, Subhash G., Luo, Dahai
Published 2022

A conserved arginine in NS5 binds genomic 3' stem-loop RNA for primer-independent initiation of flavivirus RNA replication

by Wang, Sai, Chan, Kitti Wing Ki, Tan, Min Jie Alvin, Flory, Charlotte, Luo, Dahai, Lescar, Julian, Forwood, Jade K., Vasudevan, Subhash G.
Published 2022

Luteolin restricts dengue virus replication through inhibition of the proprotein convertase furin

by Peng, Minhua, Watanabe, Satoru, Chan, Kitti Wing Ki, He, Qiuyan, Zhao, Ya, Zhang, Zhongde, Lai, Xiaoping, Luo, Dahai, Vasudevan, Subhash G., Li, Geng
Published 2017

Molecular basis for specific viral RNA recognition and 2' -O-ribose methylation by the dengue virus nonstructural protein 5 (NS5)

by Zhao, Yongqian, Soh, Tingjin Sherryl, Lim, Siew Pheng, Chung, Ka Yan, Swaminathan, Kunchithapadam, Vasudevan, Subhash G., Shi, Pei-Yong, Lescar, Julien, Luo, Dahai
Published 2016

Non-nucleoside inhibitors of Zika virus RNA-dependent RNA polymerase

by Gharbi-Ayachi, Aïcha, Santhanakrishnan, Sridhar, Wong, Yee Hwa, Chan, Kitti Wing Ki, Tan, Siok Thing, Bates, Roderick Wayland, Vasudevan, Subhash G., El Sahili, Abbas, Lescar, Julien
Published 2020

NS3 helicase from dengue virus specifically recognizes viral RNA sequence to ensure optimal replication.

by Swarbrick, C.M.D., CHANDRAKALA BASAVANNACHARYA, CHAN WING KI KITTI, CHAN SHU ANN, DALJIT SINGH, WEI NA, Phoo, W.W., Luo, D., Lescar, J., VASUDEVAN SUBHASH
Published 2020

NS3 helicase from dengue virus specifically recognizes viral RNA sequence to ensure optimal replication

by Swarbrick, Crystall M. D., Basavannacharya, Chandrakala, Chan, Kitti W. K., Chan, Shu-Ann, Singh, Daljit, Wei, Na, Phoo, Wint Wint, Luo, Dahai, Lescar, Julien, Vasudevan, Subhash G.
Published 2018

Structural insight and flexible features of NS5 proteins from all four serotypes of Dengue virus in solution

by Saw, Wuan Geok, Tria, Giancarlo, Grüber, Ardina, Subramanian Manimekalai, Malathy Sony, Zhao, Yongqian, Chandramohan, Arun, Srinivasan Anand, Ganesh, Matsui, Tsutomu, Weiss, Thomas M., Vasudevan, Subhash G., Grüber, Gerhard
Published 2015

Flexibility of NS5 Methyltransferase-Polymerase Linker Region Is Essential for Dengue Virus Replication

by Zhao, Yongqian, Soh, Tingjin Sherryl, Chan, Kitti Wing Ki, Fung, Sarah Suet Yin, Swaminathan, Kunchithapadam, Lim, Siew Pheng, Shi, Pei-Yong, Huber, Thomas, Lescar, Julien, Luo, Dahai, Vasudevan, Subhash G.
Published 2015

18F-fluorodeoxyglucose positron emission tomography as a window into human dengue pathophysiology

by Kalimuddin, Shirin, Xie, Wanying, Watanabe, Satoru, Tham, Jing Yang, Sam, Huizhen, Chan, Kitti Wing Ki, Yap, Tiang Siew, Totman, John J., Chacko, Ann-Marie, Vasudevan, Subhash G., Low, Jenny G.
Published 2022

The C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus Production

by Chan, Kitti W. K., Tay, Moon Y. F., Smith, Kate, Ng, Ivan H. W., Zhao, Yongqian, Ooi, Eng Eong, Lescar, Julien, Luo, Dahai, Jans, David A., Forwood, Jade K., Vasudevan, Subhash G.
Published 2017

The C-terminal 50 amino acid residues of dengue NS3 protein are important for NS3-NS5 interaction and viral replication

by Tay, Moon Y. F., Saw, Wuan Geok, Zhao, Yongqian, Chan, Kitti W. K., Singh, Daljit, Chong, Yuwen, Forwood, Jade K., Ooi, Eng Eong, Grüber, Gerhard, Lescar, Julien, Luo, Dahai, Vasudevan, Subhash G.
Published 2018

Pyridobenzothiazolones Exert Potent Anti-Dengue Activity by Hampering Multiple Functions of NS5 Polymerase

by Rolando Cannalire, Kitti Wing Ki Chan, Maria Sole Burali, Chin Piaw Gwee, Sai Wang, Andrea Astolfi, Serena Massari, Stefano Sabatini, Oriana Tabarrin, Eloise Mastrangelo, Maria Letizia Barreca, Violetta Cecchetti, VASUDEVAN SUBHASH, Giuseppe Manfroni
Published 2020

Cell-active carbazole derivatives as inhibitors of the zika virus protease

by Rassias, Gerasimos, Zogali, Vasiliki, Swarbrick, Crystall M. D., Chan, Kitti Wing Ki, Chan, Shu Ann, Gwee, Chin Piaw, Wang, Sai, Kaplanai, Entzy, Canko, Aleksander, Kiousis, Dimitrios, Lescar, Julien, Luo, Dahai, Matsoukas, Minos-Timotheos, Vasudevan, Subhash G.
Published 2021

A crystal structure of the dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replication

by Zhao, Yongqian, Soh, Tingjin Sherryl, Zheng, Jie, Chan, Kitti Wing Ki, Phoo, Wint Wint, Lee, Chin Chin, Tay, Moon Y. F., Swaminathan, Kunchithapadam, Cornvik, Tobias Carl, Lim, Siew Pheng, Shi, Pei-Yong, Lescar, Julien, Vasudevan, Subhash G., Luo, Dahai
Published 2015